منابع مشابه
Collagen synthesis by human fibroblasts
We have examined the combined effects of transforming growth factor-fl (TGF-,8), serum and y-interferon (y-IFN) on collagen synthesis by fibroblasts and compared the response of fibroblast subpopulations to TGF-,6. Human diploid fibroblasts were treated with TGF-/J alone and with serum or y-IFN. Cells were labelled with radioactive amino acids, and collagen production was measured as collagenas...
متن کاملThe rate of synthesis of glycosaminoglycans and collagen by fibroblasts cultured from adult human liver biopsies.
Adult human liver biopsies were cultured from normal, alcoholic hepatitis, chronic active hepatitis, fibrosis plus alcoholic hepatitis (active cirrhosis), inactive cirrhosis, and drug hepatitis. The synthesis of collagen was estimated in cultures from 58 livers by measuring the conversion of [(14)C]proline to the [(14)C]hydroxyproline of collagen; that of glycosaminoglycans in cultures from 57 ...
متن کاملLiver collagen synthesis in murine schistosomiasis.
Collagen synthesis was measured in liver slices obtained from mice with hepatosplenic schistosomiasis. Enlarged fibrotic livers from these mice contained 20 times more collagen than normal. This model of hepatic fibrosis results from an inflammatory granulomatous host response to Schistosoma mansoni ova in portal tracts, rather than from direct lover cell injury as with carbon tetrachloride-ind...
متن کاملSynthesis of basement membrane collagen by cultured human endothelial cells
Studies were performed to determine if cultured human endothelial cells synthesized basement membrane collagen. In culture, endothelial cells were attached to grossly visible membranous structures which on light microscopy were composed of ribbons of dense, amorphous material. On transmission electron microscopy, these membranous structures consisted of amorphous basement membrane, and material...
متن کاملSelective inhibition of human diploid fibroblast collagen synthesis by interferons.
The effects of alpha- and gamma-interferons (IFNs) on collagen production by confluent human diploid fibroblasts in culture were examined. It was found that partially purified alpha-IFNs and affinity purified gamma-IFNs caused greater than 50% inhibition of collagen synthesis by these cells independently of their effect on cell proliferation. Recombinant alpha-IFNs showed a similar effect (38.8...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1978
ISSN: 0016-5085
DOI: 10.1016/0016-5085(78)93623-5